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Through sophisticated molecular modifications including lipidation with a fatty acid chain, strategic amino acid substitutions, and enhanced receptor binding properties, cagrilintide achieves an extended half-life of 159-195 hours while maintaining potent biological activity

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doi: 10.1016/j.biopha.2020.110663

ZO-1 Restoration Zonula occludens-1 is the scaffolding protein that anchors tight junction complexes to the cytoskeleton