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Notably, Nrxn3 , which encodes for a synaptic adhesion protein critical for maintaining synaptic function 43 , was downregulated by GIPR antagonism and GLP-1R agonism in both the C35 GABA4 and the C35 GABA3 cluster (Fig

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Within the framework of fundamental medicine, the approach proposed by integrative physiology can be the only correct way to view the pathological state of an organism, not from the perspective of the presence of a specific disease or multiple comorbid conditions, but as a complex and unified process based on various links of pathogenesis

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