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Importantly, some of these studies showed that the loss of MOR function after chronic opioid treatment was selective because there was no change in the sensitivity to agonists at other GPCRs known to couple to the same effectors (Christie et al., 1987

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Nature 630 , 247254 (2024)

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DHT (dihydrotestosterone) drives the progressive shrinking of hair follicles, causing hair to become thinner and shorter over successive cycles until the follicle becomes dormant