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Applications & Features Model Delivery & Logistics Resources Validation Data Applications of the genOhGLP-1R mouse model Broad range of applications in the fields of metabolism, autoimmunity and neuroscience : Assess the efficacy of GLP-1R targeting compounds, such as in the context of treating type 2 diabetes and obesity Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential Features Physiological regulation and expression of the humanized GLP-1R Fully functional hGLP-1R Lack of expression of the murine target gene Model is available in a C57BL/6N background Fully functional mouse immune system Clients Customize this model Tailor this model to meet your research needs : Assess the efficacy and safety of therapeutics with multiple humanized targets Simultaneously evaluate efficacy, safety, and PK in a single model Assess the impact of the human Fc-domain of an antibody while assessing its efficacy and safety Increase tolerance to human IgG1 and more to fit your program Model Delivery & Care Read our FAQ on delivery & care here Orders are made directly with genOway

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To tie in with the JAMA article, a recent article in Atherosclerosis Plus suggests how an increase in statin use should also decrease PAD because of statins' pleiotropic effects in addition to their ability to decrease triglycerides