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Acetaminophen poisoning can be due to ingestion of a single overdose (usually as an attempt at self-harm) or ingestion of excessive repeated doses or too-frequent doses, with therapeutic intent

Diabetes Obes Metab 20(3):610619

Proceedings of the National Academy of Sciences of the United States of America 110 , 1385713862, doi:10.1073/pnas.1307698110 (2013)

Peer review Peer review information Nature Communications thanks Chengyong Tang and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Therefore, a readily available and reliable methodology of functional brain imaging is urgently required in not only patients with overt but also with covert hepatic encephalopathy

Kimberly Ferrero, Ph.D., M.Sc