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When this happens, the acetaminophen is processed through another pathway, the cytochrome P-450 system

For most patients, gastrointestinal side effects are most pronounced in the first two to eight weeks of treatment and improve substantially as the body adjusts

Available online at: (accessed April, 2026)

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Other groups requiring careful evaluation include: Patients with a history of pancreatitis a causal relationship between incretin-based therapies and pancreatitis has not been definitively established, but UK SmPCs advise caution in those with a prior history

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