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In most reports, acute kidney injury was attributed to pre-renal acute failure due to exenatide-induced nausea and vomiting, decreased fluid intake, and significant loss of fluids

That warning created significant uncertainty for men and clinicians alike, and it was based largely on earlier, smaller studies that raised concerns without providing the rigorous, large-scale data needed to confirm or refute them

Efficacy-wise, AOD-9604 produces modest results (2-3 kg over 12 weeks in trials) compared to GLP-1 agonists dramatic weight loss

Scientific Sources Teichman SL, Neale A, Lawrence B, et al

Monitoring arrangements should be clearly established