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It works by strengthening the intestinal barrier, helping proteins like ZO-1 and Occludin keep the gut lining tight, which stops harmful bacteria from entering the body

Hare GMT, Zhang Y, Chin K et al (2021) Impact of sodium glucose linked cotransporter-2 inhibition on renal microvascular oxygen tension in a rodent model of diabetes mellitus

However, the relevance of these animal findings to humans remains uncertain

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These processes were identified as being closely associated with the expression of genes such as glyceraldehyde-3-phosphate dehydrogenase ( GAPDH ), lactate dehydrogenase A ( LDHA ), glutathione peroxidase 1 ( GPX1 ), and 1,4-alpha-glucan branching enzyme 1 ( GBE1 )

[20] Women who gained excessive weight during pregnancy may have a strong clinical rationale for resuming GLP-1 therapy after weaning