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[13] Orally ingested compounds first pass through the gastrointestinal tract and gut microbiome where some xenobiotics can be metabolized before entering the bloodstream, while inhaled, intravenous, or dermal exposures enter circulation more directly
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Over 39 months mean follow-up, the primary composite outcome of MACE (cardiovascular death, non-fatal MI, non-fatal stroke) dropped 20% in the semaglutide group
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