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In a next step, the significant [11C]Raclopride displacement cluster was used as an ROI to extract individual TACs for which the lp-ntPET model was fitted again to yield dynamic BP ND estimate curves which were transformed to DA receptor occupancy: This two-step approach is done to reduce the noise inherent in the single voxel TACs

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For the enzymes affected by estradiol in one-carbon metabolism (yellow enzymes), as estradiol varies during the menstrual cycle, the multiplier of the V max of the enzyme is scaled between the male value and the female value in table 3 in [22]

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