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The primary mechanism of action of the SGLT2i is to inhibit glucose reabsorption in the proximal tubule leading to glucosuria which is in the range of 6080 grams per day (19,20)
In the head-to-head SURMOUNT-5 trial (NEJM 2025), tirzepatide produced 20.2% weight loss vs 13.7% for semaglutide at 72 weeks
Why hydrating intentionally is important Because semaglutide medications can suppress cravings and feelings of hunger, they can also affect your ability to sense thirst
Sofogianni A, Filippidis A, Chrysavgis L, Tziomalos K, Cholongitas E
Whitney Linsenmeyer, PhD, RD, Assistant Professor of Nutrition and Dietetics Daily Grams Needed The US recommends a minimum of 46-56 grams per day for adult females and males, respectively
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