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Whitford TJ, Rennie CJ, Grieve SM, Clark CR, Gordon E, Williams LM (2007)

Pharm Rev

By preferentially promoting cAMP-mediated intracellular pathways, thought to be central to insulin secretion and appetite regulation, this receptor bias may enhance metabolic efficacy while potentially reducing the activation of alternative signalling cascades associated with receptor desensitisation or adverse effects (although the clinical relevance of this remains to be fully established)

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In addition to cognitive and neuroprotective benefits, GLP-1 agonists are also being studied for their potential cardiovascular advantages in bipolar disorder patients and others

However, these data may simply reflect the presence of inflammation in GD and more especially in Graves orbitopathy