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Combination of the anti-IGF-IR Ab ganitumab and castration potently inhibits prostate cancer in animal model [113]

In this review, we highlight the data of major randomized cardiovascular outcome clinical trials of GLP-1RAs in two subsets of patients: i) Patients with T2DM ii) Patients who are overweight or obese without T2DM discussing the current evidence on their CV effects and the utility of these agents in the reduction of major adverse cardiovascular outcomes

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