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Bellato E, Marini E, Castoldi F et al (2012) Fibromyalgia syndrome: Etiology, pathogenesis, diagnosis, and treatment

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A study that compared 24 obese patients with MC-4R deficiency to 80 healthy controls (40 obese and 40 lean) found that those with MC-4R mutations consumed significantly more high-fat meals

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Patients randomized to flexible dosing windows (within 2 days) showed comparable weight loss and safety profiles to those on strict weekly schedules

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