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Insulin staining of pancreatic sections were consistent with changes in insulin secretion observed in Figure 4A with an increase in cell mass in SKO mice relative to WT mice ( Figure 4B )

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Treatment with once-weekly cagrilintide (0.16, 0.30, 0.60, 1.2, 2.4, and 4.5 mg) in combination with semaglutide 2.4 mg for 20 weeks was not associated with an increase in adverse events compared with placebo in combination with semaglutide 2.4 mg, with no unexpected safety or tolerability findings

Assay kits are also available to measure GSH as well as GSH reductase activity in cells