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sphingomyelin is the most abundant nuclear sphingolipid, and in addition to being an integral part of the nuclear matrix, it also plays structural and regulatory roles in chromatin assembly and dynamics (Yuan et al., 2024)

These findings highlight the brain AngIV/PI3K/AKT axis as a potential target for the treatment of AD

It acts as an obligate cofactor for the carnitine palmitoyltransferase (CPT) enzyme system, which shuttles long-chain fatty acids across the inner mitochondrial membrane for -oxidation [1]

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