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The comparative study by the JAMA Internal Medicine found that 853 of 71,369 individuals admitted to hospitals for bile duct and gallbladder issues were linked to GLP-1 receptors

PMID: 8001745

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GLP-1 works to regulate ones appetite and caloric intake, and the GLP-1 receptor is present in several areas of your body, including areas in your brain responsible for appetite regulation

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Thus, it demonstrates efficient clearance and limited systemic accumulation