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Furthermore, the histologic sample obtained is generally inadequate for confirming complete excision/destruction, and melanocytes extending beyond the adnexal structures may remain untreated.1,77,79 Intralesional Interferon Although a group of authors reported the clearance of 11 lesions in 10 patients treated with intralesional interferon, only 4 cases were confirmed histologically.148 A report of 6 LMs successfully treated in a patient with xeroderma pigmentosum has also been published.149 The follow-up periods reported have been very short and there is little evidence to support the use of intralesional interferon in LM.,1 5-Fluorouracil The mechanism of action of 5-fluorouracil is related to the inhibition of DNA synthesis

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doi:10.1186/s12875-019-1070-0

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[DOI] [PMC free article] [PubMed] [Google Scholar] 211.Nowak C, Hetty S, Salihovic S, Castillejo-Lopez C, Ganna A, Cook NL, et al

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