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With more than 800 peptide drugs in clinical development and nearly 200 already approved, the global peptide therapeutics market is expected to hit almost $70 billion by 2028

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That rationale must be backed by non-clinical data confirming the compound behaves as expected and by a thorough safety and toxicology program that identifies potential risks and establishes a safe starting dose for the first human administration and the maximum human exposure that should not be surpassed

PMID 21560041

In fact, a 2008 study found that after taking a 1,000 mcg oral supplement, only approximately 1.3% (or 13 mcg) of B12 was absorbed into the bloodstream