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The risk factors fall into several categories

For Systemic Application (via Subcutaneous Injection): A standard protocol for general systemic research often starts at the lower end of this spectrum

doi:10.1691/ph.2008.8157 Subbareddy P, Divakar TE (2016) Development and validation of a stability indicating RP-HPLC method for simultaneous estimation of trihexyphenidyl and trifluoperazine in pharmaceutical dosage forms

Clinical Practice Gudelines: Systemic AL Amyloidosis 2019:[49 p.]

And its not because of any magic its because these are natural substances that our bodies make and are familiar with, so thats what gives them this incredible safety profile. The FDA, however, has publicly stated that there is not enough evidence from human clinical trials on the safety or efficacy of these drugs