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Les ractions plus srieuses sont exceptionnelles et lencadrement mdical permet une gestion immdiate si ncessaire

Plan to use Protocol 2 or Protocol 3 during dose escalation, stepping back to Protocol 1 once you stabilize

However for rats, litter size was significantly decreased (by about 50%) and the number of intrauterine deaths was significantly increased (about 5-fold)in rats receiving amlodipine maleate at a dose equivalent to 10 mg amlodipine/kg/day for 14 days before mating and throughout mating and gestation

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