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An additional potential mechanism involves the interference with the regulation of renal blood flow

L-theanine intake (6 mg/kg) could prevent brain atrophy and stress vulnerability in senescence-accelerated mice prone 10 (SAMP10) mice, with the mechanism of intaking L-theanine could block the expression changes of the transcription factor neuronal PAS domain protein 4 ( Npas4 ) and Lipocalin 2 ( Lcn2 ) in hippocampus and PFC of SAMP10 (58)

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Interestingly, after 4 weeks of treatment, only males experienced higher alternation percentages indicating females required a longer period of time to respond to treatment

Sosnowska, A

Vaduganathan M, Filippatos G, Claggett BL, Desai AS, Jhund PS, Henderson A, Brinker M, Kolkhof P, Schloemer P, Lay-Flurrie J, et al