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Pruritus in cirrhosis typically affects larger body areas such as the back and abdomen, sparing smaller extremities like the soles and palms, hands, and feet

The practical protocol approach for most researchers starts at a lower dose, typically 2mg weekly, and escalates every three to four weeks based on tolerance

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This metabolite activates specific receptors ( TRPV1 ) that are crucial in how we experience pain

The documented protocol reflects a modest, once-daily research dose chosen to sit inside a tolerable window while still recruiting both gates