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TET family proteins Ten-eleven translocation (TET) proteins serve as methylcytosine dioxygenases to convert 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in an iron-dependent manner

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This altered pharmacokinetic profile increases nausea intensity and duration the most common dose-limiting side effect and shortens the effective half-life, potentially requiring more frequent administration to maintain stable receptor occupancy

The genotyping primers are listed in Table 1

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