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Potential Side Effects While Semaglutide/Pyridoxine presents many benefits, patients should be aware of possible side effects, including: Gastrointestinal issues such as nausea, vomiting, and diarrhea Injection site reactions (redness, irritation, or swelling) A risk of hypoglycemia, particularly when paired with other diabetes medications Patients should be encouraged to report any unusual symptoms and stay in close contact with their healthcare provider throughout their treatment journey