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NAC has very few documented side effects

Munzberg H, Flier JS, Bjorbaek C

The therapeutic strategies involving the use of antioxidants in cancer treatment can be executed through two main approaches: targeting ROS with non-enzymatic antioxidants and Nrf2 activators 120 or using SOD mimics, NAC, and GSH esters, including NOX inhibitors

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However, overdose remains a leading cause of acute liver failure, primarily characterized by centrilobular (zone 3) hepatic necrosis, oxidative stress, mitochondrial dysfunction, and sterile inflammation