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Treatment Sessions: Each session lasts approximately 4560 minutes

AAV2-based vectors have been used in clinical trials to deliver therapeutic genes to the striatum or SNpc, showing safety and moderate benefit (Niethammer et al., 2017

Dosing begins with 5 mcg twice a day, one hour before breakfast and dinner

All authors have read and approved the final version

As a result of being peptides, GLP-1 RAs typically have to be given by subcutaneous (s.c.) administration as twice daily (BID) (exenatide) [15, 16], once daily (OD) (lixisenatide [17, 18] and liraglutide [19, 20]) or once weekly (OW) (dulaglutide [21, 22], prolonged-release exenatide [23, 24] and semaglutide [25, 26]) dosing regimens, based on their in vivo half-lives [6]