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Melanosis coli is a darkening of the colonic mucosa caused by the accumulation of lipofuscin particles within the macrophages of the lamina propria of the colonic mucosas a result of long term exposure to anthraquinone-containing laxatives

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The authors stated that the ECM and immune-related signature genes, together with extensively infiltrating immunocytes, may play a role in the development of POP (Wu et al