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2002] and induced fit models [Koshland, 1958], early ideas of enzyme action imagined they induced changes in the surrounding water, which then accelerated reactions in molecules nearby [Kohler, 1973]

HUBERMAN: Instances of people say severing off a finger or even a hand or things of that sort, and then it being placed by a surgeon, of course, or in some cases, these were battlefield situations into the gut as a way to preserve that finger or hand and keep it alive essentially, and then to graft it back on or to make an attempt to graft it back on so that the person could then use those fingers or that hand again

10.1016/j.sbi.2022.102368

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12 , e231284 (2019)