I am in Germany and noticed my first B12 prescription included this, so I assume it is safe
Nocturnal enuresis (a pediatric indication - attributed to its antimuscarinic side effects) Contraindications: Drugs that inhibit monoamine oxidase (MAOI's) taken w/in 14 days, acute recovery period after a myocardial infarction, or history of drug hypersensitivity Side Effects: drowsiness dry mouth & eyes constipation orthotstatic hypotension mild tremor sweating agitation nausea tinnitus Overdose & Treatment: See Amitriptyline
Also, patients with pregnancy, breast feeding, patients suffering from endocrine diseases, autoimmune disorders, chronic debilitating diseases like malignancy, decompensated cardiac, pulmonary, renal, or hepatic diseases were ruled-out
If you are comparing semaglutide to tirzepatide or evaluating options like retatrutide , storage requirements should factor into your decision
10.1038/mp.2012.141 34 GreigN
[80] investigated at the cognitive dose-response curves related to IN-insulin delivery in persons with AD or amnestic MCI