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VEGF also regulates and shapes immunosuppressive TME by inhibiting dendritic cell maturation, preventing antigen presentation, and by polarizing macrophages toward an M2 phenotype

Melasma mainly affects the upper lip, cheeks (often called the malar region), the bridge of the nose, and the forehead

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The mevalonate pathway is important for growth, spore production, and the virulence of Phytophthora sojae

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