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The immunosuppressive cytokines and checkpoints in the GBM TME derive not only from tumor cells, but also from TAMs and regulatory T cells (Tregs), the suppressive subset of CD4+ T cells

Findings: Steroid hormone biosynthesis pathways, including androstenedione metabolism as well as androgen and estrogen metabolism, were overrepresented by metabolites that significantly discriminated samples in the +ADT from the ADT group

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10.1016/0014-2999(74)90238-6 84 LouahedJ.TodaM.JenJ.HamidQ.RenauldJ.-C.LevittR