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To develop kinase inhibitors that simultaneously target Src, AXL and IGF-1R activities, Lee and colleagues (2021) synthesized a series of compounds based on phenylpyrazolo[3,4-d]pyrimidine conjugation with 2,4-bis-arylamino-1,3-pyrimidines (I2)

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This review also highlights the different mechanisms associated with the generation of ROS in the plant cell