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Tyrosinase is the enzyme that converts signals UV exposure, inflammation, hormonal triggers into melanin production
Molecular formula CHCuNO Molecular weight 403.93 g/mol CAS number 49557-75-7 Amino acid sequence Gly-His-Lys (Cu-complex) Number of amino acids 3 Purity 99% (HPLC) Appearance / form White lyophilized powder Reconstitution Bacteriostatic water Storage 20 C, protected from light
The involvement of medicinal chemists will also help delineate the impacts of different structural changes, such as different terminal linkages with GSH ( C -terminal, S -terminal, and N -terminal), on binding selectivity and efficiency, and establish structure-activity relationships (SAR) for the development of glutathione transporter-based brain targeting ligands
Next, we introduced multiple mutations in HGF, including point mutations (W321R, E336R, E361R, R373E, and Y376A), double mutation (W321R/Y376A), and triple mutation (W321R/E361R/Y376A), designed to weaken the interface III
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