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This decline is frequently cited as the rationale for exogenous supplementation in research models

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The pericentral region had higher reaction rates of glucokinase (v GK ), fructose-2,6-bisphosphatase (v FBP2 ), aldolase (v ALD ), glyceraldehyde-3-phosphate dehydrogenase (v GAPDH ), and pyruvate kinase (v PK ) compared with the periportal region, and the positive lactate dehydrogenase reaction rate was indicative of glycolysis promotion and lactate (Lac) production (Miethke et al., 1985)

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