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Regulatory Status AOD-9604 is not FDA-approved for any medical use and is listed by the FDA as a bulk drug substance that may present safety risks. Clinical development was halted after Phase IIb trials failed to meet efficacy endpoints. Summary AOD-9604 is a synthetic analog of the HGH 177191 fragment developed for fat-metabolism research

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It also upregulates growth factors, modulates inflammatory cytokines, activates FAK-paxillin signaling (which drives cell migration into injury sites), and supports collagen synthesis

Preclinical evidence base The peer-reviewed literature for the three peptides is uneven

Six h after seeding (or 24 h after doxycycline induction for MYCN-regulatable cell systems), the cells were treated with 50 L of drug(s) or vehicle and incubated at 37C for 72 h

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