Most researchers find that gut-related side effects fade substantially after 8-12 weeks on a stable dose
There are also two stop and seek care signals worth stating plainly as reference context, because they are the classs more serious events: severe, persistent abdominal pain (which may radiate to the back and can signal pancreatitis) and symptoms of gallbladder disease such as right-upper-quadrant pain, fever, or jaundice
Cardiovascular outcomes trials in type 2 diabetes: where do we go from here
Withdrawal symptoms can also occur when individuals stop taking GLP-1 medications: Reduced side effects: While semaglutide or tirzepatide can lead to side effects like acid reflux, nausea, constipation and abdominal pain, stopping the medication can reduce these side effects
Contact your GP if heartburn or reflux symptoms persist for three weeks or more, or if you develop dysphagia, persistent vomiting, or unexplained weight loss
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