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Thus, observed potent induction of ferroptosis, GPX4-dependent novel suppression of mTOR pathway and DNA damage repair response in preclinical in vitro model of TC supports GPX4 targeting for therapeutic benefit in advanced therapy-resistant thyroid cancers

Further, changes in glucose metabolism regulated ROS production and inflammation, particularly inflammasome-mediated inflammation, in both human and rodent myeloid cells (Zhou et al., 2011

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Response varies by stage

Glutathione's unique role lies in its ability to recycle and regenerate other antioxidants like vitamin C and vitamin E, making it essential for the body's defence against harmful molecules