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For individuals with prediabetes or early diabetes, this improved sensitivity may help restore more normal glucose metabolism

Retatrutide activates three hormone receptorsGLP-1, GIP, and glucagonwhile tirzepatide activates only two

Gastrointestinal side effects and strict dietary adherence are potential barriers, particularly in long-term settings [160,161]

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How Will GLP-1s Change Restaurant Menus? Montero, A., Sparks, G., Presiado, M., and Hamel, L

In patients with type 2 diabetes receiving insulin, GLP-1 RA initiation may require insulin dose reduction to minimize hypoglycemia risk