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Acute Fat Oxidation and Energy Expenditure Acute single administration of AOD9604 in wild-type mice produced a significant increase in fat oxidation and energy expenditure, with an associated reduction in glucose oxidation

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6a, b) Delaying G6PDi-1 treatment for 1 h post-stimulation allowed for substantial cytokine production, indicating that G6PD and the PPP likely play an important role in the early signaling events following stimulation

Jun 1 2024;160(6):600-605

In mouse studies, the drug reduced lean mass primarily by shrinking organs like the liver rather than skeletal muscle