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The NF1 gene, for example, encodes neurofibromin 1 protein, a negative regulator of Ras proteins, and can lose its function in both CM and MM

Cofactor for L-methylmalonyl-coenzyme A mutase 5-Deoxyadenosylcobalamin is required by the enzyme that catalyzes the conversion of L-methylmalonyl-coenzyme A to succinyl-coenzyme A (succinyl-CoA), which then enters the citric acid cycle ( Figure 2 )

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