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A attracts and activates microglia and astrocytes, leading to the release of pro-inflammatory mediators such as TNF, IL-6, IL-2, and IL-1, as well as reactive oxygen and nitrogen species produced by oxidative stress, which ultimately leads to neuronal cell death (35)

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The commenters stated that the current APC assignment does not adequately reflect the resource costs associated with these specialized contrast-enhanced ultrasound procedures