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DPP4 (Dipeptidyl Prptidase-4) GLP-1

While many of these molecules showed promising results in preclinical rodent, minipig, or non-human primate (NHP) models, they could not achieve sufficient therapeutic windows to observe clinical weight loss without adverse events such as cardiac activation ( MK-0493 MK-0493 is an orally available small molecule developed by Merck ( Figure 2 )

Fan H, Gong N, Li TF, Ma AN, Wu XY, Wang MW et al (2015) The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating -endorphin release from spinal microglia

Carnitine and acylcarnitine analysis quantifies free L-carnitine (the molecule that transports fatty acids into mitochondria) and its acyl derivatives using LCMS/MS

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