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The body, more often than not, has less free cysteine available than the synthesis machinery would otherwise use

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The channel is also activated by phorbol esters, low pH, citrate, arachidonic acid, exogenous chemicals (bisandrographolide A) and heat (24C ) (Gler et al., 2002

Oxidative stress is crucial in atherogenesis (144151), suggesting that a specific antioxidant/prooxidant imbalance, characterized by a weak GSH-related enzymatic antioxidant shield present in human atherosclerotic lesions, may be involved in atherogenic processes in humans (152)

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