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FDA approval is expected in 2027-2028 if Phase 3 trials are successful

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Aging Healthfully Book 2011

NCT02570672 ( Metformin for Preventing Frailty in High-risk Older Adults ) is a Phase 2 study involving 120 subjects aged 65 to 90 years old with pre-diabetes and treated with 1000 mg metformin bid, versus placebo, and due for completion in October 2024

A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss

How to manage it: Cook vegetables thoroughly to ease digestion