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An analysis of studies which involved 49,395 human pregnancies with periconceptional GLP-1 RA exposure found a small but statistically significant association with renal malformations in children, but the researchers said this likely reflects residual confounding by maternal disease severity

For athletes or active individuals, its benefits lie primarily in fat mass reduction and appetite regulation , though it does not appear to preserve lean body mass to the same degree suggested in Tirzepatide trials

Understanding these details helps improve treatment strategies