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Tirzepatide activates both GLP-1 and GIP receptors, representing a dual mechanism that research suggests may produce greater weight loss than GLP-1 activation alone

Distinct from prior reviews that predominantly focus on a single drug class or limited clinical indications, this article systematically contrasts the mechanistic pathways, therapeutic efficacy, and safety profiles of GLP-1RAs versus GLP-1/GIP dual receptor agonists

Ongoing treatment helps maintain the results achieved during the initial weight loss phase

Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis

Phase 3 trials (TRIUMPH program) recruiting at hundreds of US sites

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