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Specific commercial kits were used to assess liver TAG, malondialdehyde (MDA), superoxide dismutase (SOD), catalase, total antioxidant capacity, monoamine oxidase, succinate dehydrogenase, ATP, Na + K + ATPase, Mg ++ -ATPase, Ca ++ ATPase and 8-hydroxydeoxyguanosine (Jiancheng Bioengineering Institute) from six fish in each group

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The results were clear: mazdutide 6 mg produced greater weight loss (10.29% vs 6.00%) and better glycemic control (HbA1c reduction of 2.03% vs 1.84%) than semaglutide 1 mg over 32 weeks

Similarly, inhibition of CD38 in aged mice boosted NAD + levels, improving exercise capacity, but in this case, no significant changes in mitochondrial biogenesis-related genes were observed 138

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