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Risk Tolerance and Side Effects Tesamorelin, due to its strong GH-releasing effect, may lead to: Joint discomfort Swelling or redness at the injection site Elevated blood glucose Sermorelin, by contrast, typically causes fewer side effects such as: Mild headaches Injection site irritation Occasional nausea or dizziness Those with sensitive systems or pre-existing conditions may benefit more from Sermorelins gentler action