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Serious adverse effects requiring clinical vigilance include: Lactic acidosis : A rare but potentially fatal complication of metformin, particularly in patients with renal impairment (eGFR 10%), symptomatic hyperglycemia, diagnostic uncertainty, or recurrent hypoglycemia

Impact on Type 2 Diabetes and Obesity The development of GLP-1 receptor agonistsdrugs that mimic GLP-1s actionshas transformed the management of type 2 diabetes and obesity

doi: 10.1111/bcp.15209 [4] Andr J Scheen

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